David A. Sinclair, Ph.D. A.O. is a tenured Professor in the Genetics Department at Harvard Medical School. He's co-director of the Paul F. Glenn Center for the Biology of Aging, a professor at The University of New South Wales (UNSW), an honorary Professor at the University of Sydney and co-founder of the journal Aging.
Recent episodes featuring David Sinclair
“Your genes are not your destiny.”David Sinclair, PhDAging is inevitable. Everybody grows old. Everyone dies.We accept these statements as fact.But what if they're just stories based on history and our current understanding of biology?What if everything we think we know about aging is about to change?Across the globe, scientists are working on treatments and therapies that are designed to extend healthy human lifespans well beyond what we know today.At the bleeding edge of such breakthroughs you will find David Sinclair, PhD, one of the world’s leading scientific authorities on longevity, aging and how to slow its effects.Returning for his second appearance on the podcast, David is a professor in the Department of Genetics and co-director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School. He obtained his Ph.D. in Molecular Genetics at the University of New South Wales, Sydney in 1995 and worked as a postdoctoral researcher at M.I.T. where, among other things, he co-discovered the cause of aging for yeast.The co-founder of several biotechnology companies, David is also co-founder and co-chief editor of the journal Aging. His work has been featured in a variety of books, documentaries, and media, including 60 Minutes, Nightline and NOVA. He is an inventor on 35 patents, has been lauded as one of the Top 100 Australian Innovators, and made TIME magazine’s list of the 100 most influential people in the world.In addition, David is the author of Lifespan: The Revolutionary Science of Why We Age -- and Why We Don't Have To -- a New York Times bestseller that proposes a radical new theory of aging. As he writes: “Aging is a disease, and that disease is treatable.”Last year I convened my first conversation with David (RRP #436), a scintillating and science-heavy primer on all things human lifespan, aging and longevity. It was a runaway hit with the listeners -- and left me wanting to know more.So today we pick up where we last left off, diving deeper into the physiological mechanisms that contribute to biological degeneration. And we go further into the current state of research to better understand what contributes to aging and what can be done to counteract it.Call him a dreamer, but David believes living to 200+ is a plausible reality. If you could double your lifespan, how would this impact how you choose to live? What would it mean for the future of humanity? And for the ecological stability of the planet? The implications are profound.Equal parts philosophic and scientific, this conversation will forever change the way you think about why you age and what you can do about it. And it will leave you armed simple lifestyle practices you can deploy -- intermittent fasting, cold exposure, exercising with the right intensity, and eating less meat -- that will help you live younger and healthier for longer.Brilliant and lovely, it’s an honor to once again share this man's wisdom with you today. So break out that pen and paper, because you're going to want to take notes on this one.The visually inclined can watch it all go down on YouTube. And as always, the audio version streams wild and free on Apple Podcasts and Spotify.I sincerely hope you enjoy the episode.Peace + Plants,Listen, Watch & Subscribe             Apple Podcasts | YouTube | Spotify | Stitcher | Google PodcastsThanks to this week’s sponsorsOn Running: Born in the Swiss Alps, On Running is the world's fastest growing running brand. From their patented cushioning system to their gorgeous minimal design aesthetic, On has become my got to for all my trail and road running needs with gear that fits, performs and looks great. To learn more about On go to on-running.com/richroll, pick your favorite shoe or apparel piece, and run in it for 30 days after which you can keep ‘em or return ‘em for a full refund no questions asked - an amazing no risk deal.Squarespace: The easiest way to create a beautiful website, blog, or online store for you and your ideas. Save 10% at checkout when visit squarespace.com/richroll and use the offer code RICHROLL at checkout.Zip Recruiter: Search for jobs hiring in your area using ZipRecruiter’s job search engine – the best way to find a job. To find jobs hiring near you and apply with just 1 click, visit: ziprecruiter.com/richrollNote: One of the best ways to support the podcast is to support the sponsors. For a complete list of all RRP sponsors and their respective vanity url's and discount codes, visit my Resources page and click "Sponsors".SHOW NOTESCheck out David's NYT bestseller: Lifespan: The Revolutionary Science of Why We Age -- and Why We Don't Have To*Connect With David: Website | Facebook | Twitter | Instagram | LinkedInLife Biosciences: Life BiosciencesPodcast Notes: David Sinclair on The Rich Roll PodcastHarvard Medical School: The Sinclair LabHarvard Medical School: Rewinding The ClockHarvard Magazine: Anti-Aging Approaches: David Sinclair's anti-aging scienceTIME Magazine: Is an Anti-Aging Pill on the Horizon?TIME Magazine: This Compound Can Reverse Aging in Mice. Will It Work in People?Longevity Facts: NMN and NAD Reverse Aging of Blood Vessels in New StudyInside Tracker: Q&A: How Harvard's David Sinclair Unlocked His Own Fountain of YouthSlate: Could A Pill Slow Aging? Geneticist David Sinclair Thinks SoNext big Future: Anti-Aging Researcher David Sinclair Takes Metformin, NMN, NAD for LongevityYouTube: (VIDEO) David Sinclair Slowing down Aging | My NMN JourneyTedMed: (VIDEO) "Can a pill a day help keep aging away?" | David Sinclair, PhDBook: Now We Are Six (Winnie-the-Pooh)* by A.A. MilneSupplement: M98 Micronized Resveratrol by Revgenetics*Related Podcasts You Might Enjoy:RRP #436: David Sinclair On Extending Human LifespanRRP #367: Fasting For Longevity With Valter Longo, Ph.D.RRP #139: How To Live To Be 100+ With Dan BuettnerRRP #209: Rhonda Patrick, PhD On Longevity, Epigenetics & Microbiome HealthThanks to Jason Camiolo for production, audio engineering and show notes; Margo Lubin and Blake Curtis for video, editing and graphics; portraits by Ali Rogers; and theme music by Ana Leimma.*Disclosure: Books and products denoted with an asterisk are hyperlinked to an affiliate program. We are a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for us to earn fees by linking to Amazon.com and affiliated sites.for 1000s of delicious, customized plant-based recipes & so much more, check out our Plantpower Meal PlannerHOW CAN I SUPPORT THE PODCAST?Tell Your Friends & Share Online!Subscribe & Review:  iTunes | Spotify | Stitcher | Soundcloud | Google PodcastsDonate: Check out our Patreon accountSupport The Sponsors: One of the best ways to support the podcast is to support our sponsors. For a complete list of all RRP sponsors and their respective vanity url's and discount codes, visit my Resources page and click "Sponsors".
Aging is a disease.Everyone gets old. But did you ever think of the symptoms of aging as a disease that can be cured?I'd heard about Dr. David Sinclair and his ground-breaking longevity research, and I knew he would be a fascinating person to interview about this idea.We ended up going really deep into the science of why we age, how to reverse it, and what is actually in our control.David told stories he'd never shared before, and I kept asking questions because I was so interested in what he was telling me.David Sinclair is a professor in the Department of Genetics and co-director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School. He is an inventor on 35 patents and has received more than 35 awards and honors. In 2014, he was on Time Magazine’s list of the “100 Most Influential People in the World,” and listed as Time's Top 50 in healthcare in 2018.In this conversation, we discussed all of my top questions on why we age, how much of it is reversible, and all of the ways I've heard to increase your longevity and health.David is a wealth of wisdom on all these topics, and he also shared some of the hardest times of his life, including watching his mother die of lung cancer and why that impacted his work so much.If you are committed to improving your health and living a long and healthy life, this conversation is a must-listen in Episode 904.Is it possible to reverse death? (7:42)What are the main ways to turn on the longevity genes? (9:30)How do you say no to all the food offers around you? (17:30)How did you get fascinated by longevity and anti-aging? (19:15)How did you recover from a major career setback? (37:06)What was the biggest lesson you learned from a year of being homeless? (49:28)How important are heat and cold therapy to anti-aging? (59:38)What is the ideal way to use fasting to improve your health? (1:05:42)How old do you think you’ll be able to live? (1:14:15)How much does inflammation play into the longevity of your life? (1:20:44)How our body’s built-in defenses against aging work (1:12)Why 3 meals a day is too much food for most people (10:09)The main benefits of a plant-based diet for longevity (13:13)Why it’s important to remember that there will always be another meal (15:10)Why death is so shocking to us even though it happens all the time (21:01)The molecule that has been proven to protect against a variety of diseases (29:34)The story that David has never told of how he was homeless after college (44:45)How cells lose their ability to stay young (55:32)Lewis’ experience doing a cold-exposure intensive in Poland with Wim Hof (1:08:45)Plus much more...If you enjoyed this episode, check out the video, show notes and more at http://www.lewishowes.com/904 and follow at instagram.com/lewishowes
David Sinclair, professor of genetics at Harvard Medical School, discusses his new book "Lifespan", which distills his cutting-edge research findings on the biological processes underpinning aging. Sinclair describes lifestyle hacks we can undertake now to combat aging, as well as future scientific breakthroughs that promise to slow down—and even reverse—the aging process. Get the book: https://goo.gle/2LXCd2P  Moderated by Sam Phippen. Visit http://g.co/TalksAtGoogle/WhyWeAge to watch the video.
My guest on today's podcast - Dr. David Sinclair, an acclaimed Harvard Medical School scientist and named as one of Time’s most influential people - just wrote a paradigm-shifting book. It’s a seemingly undeniable truth that aging is inevitable. But what if everything we’ve been taught to believe about aging is wrong? What if we could choose our lifespan? In this groundbreaking new book , Dr. Sinclair, leading world authority on genetics and longevity, reveals a bold new theory for why we age. As he writes: “Aging is a disease, and that disease is treatable.” This eye-opening and provocative work takes us to the frontlines of research that is pushing the boundaries on our perceived scientific limitations, revealing incredible breakthroughs—many from Dr. David Sinclair’s own lab at Harvard—that demonstrate how we can slow down, or even reverse, aging. The key is activating newly discovered vitality genes, the descendants of an ancient genetic survival circuit that is both the cause of aging and the key to reversing it. Recent experiments in genetic reprogramming suggest that in the near future we may not just be able to feel younger, but actually become younger. Through a page-turning narrative, Dr. Sinclair invites you into the process of scientific discovery and reveals the emerging technologies and simple lifestyle changes—such as intermittent fasting, cold exposure, exercising with the right intensity, and eating less meat—that have been shown to help us live younger and healthier for longer. At once a roadmap for taking charge of our own health destiny and a bold new vision for the future of humankind, Lifespan will forever change the way we think about why we age and what we can do about it. During our discussion in which we take a deep dive into "Lifespan", you'll discover: -What does a typical day look like for a scientist at Harvard?...5:45 -Dr. Sinclair's method of speeding up the aging process in mice...8:30 -Cellular Reprogramming 101...14:30-A device that determines a human genome via a USB connection...23:15 -Whether you can predict your lifespan with your current DNA data from 23andMe...25:15 -The correlation between protein consumption and longevity...29:30 -The importance of a proper methionine and glycine balance...38:00 -The effects of NMN on fertility...49:15 -Uncoupling proteins, and whether DMP supplements are a good idea...53:10 -Resveratrol, stressed wine and fruit, and longevity...58:00 -Cancer breakthroughs in which Dr. Sinclair is currently interested...1:03:15 -David's personal protocol...1:10:30 -And much more... Resources from this episode: - - Book:   - - - - - - - - - Episode sponsors: -: My personal playground for new supplement formulations, Kion blends ancestral wisdom with modern science. Ben Greenfield Fitness listeners, receive a 10% discount off your entire order when you use discount code: BGF10. **Take advantage of the HUGE Black Friday deals thru December 2! -: After using the Joovv for close to 2 years, it's the only light therapy device I'd ever recommend. Give it a try: you won't be disappointed. Order using and receive a month's supply of Kion Berry Aminos absolutely free. -: Organic brands you love, for less. Your favorite organic food and products. Fast and free shipping to your doorstep. Receive a gift card up to $20 when you begin a new membership using . -: Whether you’re shopping for the perfect holiday gift or just trying to craft a smart, relaxed style of your own, UNTUCKit is the way to go. Receive 20% off your order when you use discount code: GREENFIELD. Do you have questions, thoughts or feedback for David or me? Leave your comments below and one of us will reply!
r. David Sinclair discusses resveratrol, NAD, and DNA methylation
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Boston, MA, USA
Episode Count
Podcast Count
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11 hours, 42 minutes