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Exogenous ketones are lauded by many for their endurance performance enhancing properties, but their impact on blood acidity is detrimental to performance and can even counteract their otherwise positive effects. Dr. Chiel Poffe and his partners conducted a study to learn if Bicarbonate Unlocks the Ergogenic Action of Ketone Monoester Intake in Endurance Exercise, and what they learned was surprising. Tune into this episode to learn the science behind ketones and bicarbonate, and how to introduce them into your training regimen to get faster.

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SCIENCE OF GETTING FASTER PODCAST

The Science of getting Faster Podcast cuts through the noise and talks directly to the scientists doing the latest research into how to become a faster cyclist, stronger athlete, and healthier person.

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TOPICS COVERED IN THIS EPISODE:

00:00 Intro

01:17 Podcast Begins

01:58 - Dr. Poffe’s background and the story of his research on Ketones

02:52 - His research with Dr. Peter Hespel of Deceuninck Quick Step

03:11 - What are ketones and ketone esters?

04:44 - Why would someone want ketones in their blood while exercising?

05:43 - The difference between ketone salts and ketone esters

06:52 - Dr. Poffe’s study and why he decided to combine ketone and bicarbonate

08:55 - Performance of Ketone vs. placebo in the studies

09:55 - What does he think happened in the first study? 

10:38 - The new study: introducing bicarbonate and what the purpose is.

11:12 - Why Chad finds the study methodology to be valuable

11:36 - Why his research always seeks to mimic real-world conditions

12:32 - What is Bicarbonate?

13:17 - Buffering systems in skeletal muscle

13:56 - How do you get/ ingest bicarbonate?

14:39 - The study method: How big was it?

15:27 - The study methodology and controls

17:24 - Nate summarizes the study’s efforts, cost of dosage, and amount of dose

19:29 - Timeframe of the test: dinner, morning, and timing of exercise

19:53 - Why was it important to control the amount of carbs ingested?

21:32- What was the dinner given to the subjects?

22:15 - What were the study’s results? 

23:19 - Conclusions about how this might apply to a race (and timing limitations)

24:52 - Avoiding gastrointestinal issues with sodium bicarbonate

25:56 - Perception of hunger and appetite in the study groups

28:07 - Asking the subjects to identify what they’d taken (placebo vs. esters, etc)

29:11 - The purpose of blinding power and HR data 

30:35 - What the study does and doesn’t suggest about ingesting ketones

31:36 - Blood ketone levels and perception of fatigue

32:04 - Should you always supplement ketones with bicarbonate?

33:11 - Outro

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