Yemen currently faces the “world’s worst cholera outbreak in the midst of the world’s largest humanitarian crisis,” according to a joint statement issued by UNICEF, the World Food Programme (WFP) and the World Health Organization (WHO) in July 2017. In light of this multidimensional humanitarian crisis, this podcast will bring together medical experts and humanitarian practitioners to discuss the epidemiological implications and medical treatment of Yemen’s cholera epidemic amidst an active armed conflict, as well as the ongoing challenges of maintaining humanitarian assistance and protection operations to mitigate the devastating impact of this crisis on vulnerable populations.