Episode from the podcastHigh Intensity Health with Mike Mutzel, MS

Abnormally Metabolized Estrogen as a Cancer-Causing Compound w/ Eleanor Rogan, PhD

Released Friday, 3rd July 2020
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Cancer researcher Eleanor Rogan, PhD, discusses the details about how your liver can transform your own hormones into cancer-causing compounds (AKA carcinogens).

Briefly, some of us have variable activities of important enzymes that metabolize estrogens in our liver.

Imbalances in these enzymes create “sticky estrogens” that can cause mutations in DNA which, over time, can lead to cancer.

Here are the full details:

Here are some important time stamps!

07:18 How estrogens become carcinogens
10:40 Higher levels of estrogen-DNA adducts in women with ovarian cancer
13:50 If your catechol-O-methyltransferase is not working well, your catechol estrogen can go on to become a quinone and react with DNA.
20:36 Why estrogen-DNA are analogous to taking a step off the DNA ladder
27:02 Men with prostate cancer have high levels of estrogen-DNA adducts.

Hope you gather some insights from this discussion,

Mike

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