Hemoglobin A1 (HbA1c) measurement is widely used in the management of type 2 diabetes mellitus (T2DM). However, expert consensus and professional guidelines conflict as to the correct use of this tool for diagnosis and therapeutic decision-making. In this podcast, Zachary Bloomgarden, MD, argues that a "one-size-fits-all" approach to interpretation and use of HbA1c is inherently flawed. He discusses the reasons and strategies for individualizing treatment goals and HbA1c targets in patients with T2DM.