When faced with patients with chronic, difficult-to-diagnose conditions, integrative doctors need to look past traditional disease categories. Mast Cell Activation Syndrome, sometimes popularly known as histamine Intolerance, helps explain why patients are stuck. Dr. Tania Dempsey, medical director of Armonk Integrative Medicine in New York, explains how diverse conditions like multi-system allergy, pain syndromes, skin problems, depression and anxiety, IBS, prostate and bladder pain, vulvodynia, endometriosis, and PMS are often remediable with natural interventions. How is MCAS diagnosed? What are common MCAS triggers? Is a low histamine diet effective in alleviating symptoms? What supplements are beneficial for MCAS?