Driven by a pandemic unprecedented in our lifetimes —a virus that has killed our neighbors, our friends, our families—we are witnesses to the massive international effort to create COVID-19 vaccines and get shots in arms. The vaccines were developed in record time, but they evolved from centuries of experimentation and science. “LONG SHOT: THE 250-YEAR JOURNEY TO THE COVID-19 VACCINES” travels back in time to the long-forgotten first inoculators and connects them to the research, methods, and people behind today's vaccines.