Featuring articles on systematic or test-guided treatment for TB in HIV, an observational study of hydroxychloroquine in Covid-19, trastuzumab deruxtecan for HER2-positive gastric cancer, renin–angiotensin–aldosterone system blockers and Covid-19, reconsidering PSA screening, and a new twist on RNA vaccines; a case report of a man with acute respiratory failure and unclear goals of care; and Perspective articles on grading changes for USMLE Step 1.