Featuring articles on allopurinol and kidney function in type 1 diabetes, the effects of allopurinol on progression of chronic kidney disease, the effect on patient safety of eliminating extended resident physician shifts, higher-dose hydroxyurea for sickle cell anemia, and black patients and white patients with Covid-19; a review article on salicylate toxicity; a case report of a girl with severe psychological distress after family separation; and Perspective articles on physician burnout; on kinder, gentler dementia-friendly Alzheimer’s care; and on how medical education is missing the bull’s-eye.