In this twenty-first episode, Nichola Conlon provides a scientific background, introducing sirtuins and NAD. She then explains why popular NAD+ boosters, NR and NMN, are first-gen products.

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She details how Nuchido formulated the first second-gen product by taking a novel whole systems approach. Lots of NAD, anti-aging, and nutraceutical discussion along the way.Topics we discussed in this episode

Recent personal experience with COVID-19Her molecular biology PhD focusSystems pharmacologyHelp from Aubrey de GrayDisillusioned with drug developmentFounding NuchidoWhat are Sirtuins? What is NAD?Importance of NAD. Why Boost NAD Levels?Inefficiency of First-Gen NAD Supplements: NR and NMNThree ingredients to boost NADPure NAD limitationsNicotinamide Riboside (NR)Nicotinamide Mononucleotide (NMN)60% increase in NAD "only"Second-gen, demonstrated it can be done much better if you take a whole systems approachImportance of NAD salvage pathwayPARP enzymesInability to power sustained high-levels because of salvage pathway deteriorationFirst-gen may not be great for epigeneticsIncreases expression of the enzymes in the salvage pathway that are known to decline with ageIngredients that reduce the expression of other processes that are actually wasting NADEnzyme called CD38Inflammatory levels - CD38 just chews up NADMultiple things that you can do to fix the cell before you even need to put precursors in.NAD decreases with ageDo we Need NAD Supplements?Sirtuins and mitochondrial biogenesisBoosting your NAD levels, improves mitochondrial function.Multiple reasons that are causing the NAD to decline, boosting as with first-gen only the amount of raw material that your cell has is quite naïveSecond-gen helps fixe your body's natural ability to make and recycle its own NADNuchido TIME+ boosts NAD on average by 242%, four times more than the 60% widely cited for first-genChromaDex vs Elyisum HealthTerms B3, niacin, nicotinamide, nicotinic acid, NRAbram Hoffer and orthomolecular medicineNicotinamide is not likely to be a sirtuin inhibitor,How to measure NAD levelsNuchido TIME+ ingredientsAlpha lipoic acid (ALA) and effects on AMPKConversion of NADH to NAD+Drift more towards having more NADH in your cell with agePathway called NQO1, converts NADH back to NAD+ALA is a really powerful antioxidant, activates NRF2ALA vs ALA-RSophora Japonica Extract Rutin, senolyticNAMPAging is an inflicted cascade disorder

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Nuchido (Company Website)ChromaDex (Company Website)Elysium Health (Company Website)Elysium Health, Inc. Loses Appeal of Patent Challenge Decision (Press Release)Orthomolecular Medicine (Wikipedia Entry)Abram Hoffer (Wikipedia Entry)Niacin: The Real Story: Learn about the Wonderful Healing Properties of Niacin (Amazon, Book)Orthomolecular Medicine for Everyone (Amazon, Book)GlycanAge (Company Website)