In this nineteenth episode, Stephen Matlin introduces telomere biology. He details how testing services typically use Q-PCR which provides an average telomere length and why that doesn't really mean anything.

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Instead the percentage of critically-short, measured using Q-FISH, does. Finally he chats about supplements - telomerase inducers - for growth.Topics we discussed in this episode

Introduction to telomere biologyHayflick limit, senescent cells, apoptosisTelomeres and the hallmarks of agingQuantitative PCR derived average telomere length vs shortest telomeresCoefficient of variation of lab samplesRole of supplements in supporting our telomeres and overall biological functionDeclining nutrition in even vegetablesTelomerase inducers TA-65 and TAM-818Telomerase enzymeHenrietta Lacks cells, cancer and the Hayflick limitTelomerase supplements and cancerTelomerase inducer Telomere Benefits™Providing biological age scores using telomere measurementsTelomere length and correlation with healthspanImproving upon biomarker Prostate Specific Antigen with Prostate Telomere Associate Variance

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LifeLength.com (Company Website)T.A. Sciences TA-65 (UK/Europe)T.A. Sciences TA-65 (Amazon.com)Hayflick, His Limit, and Cellular Ageing (Paper)The Hayflick Limit (Embryo Project Encyclopedia)The End-Replication Problem (Paper)Leucocyte Telomere Length And Risk Of Cardiovascular Disease: Systematic Review And Meta-analysis (Paper)Association Between Leucocyte Telomere Length And Cardiovascular Disease In A Large General Population In The United States (Paper)The Hallmarks of Aging (Paper)Coefficient of Variation (Wikipedia Entry)A Natural Product Telomerase Activator Lengthens Telomeres in Humans: A Randomized, Double Blind, and Placebo Controlled Study (Paper)The Telomerase Activator Ta-65 Elongates Short Telomeres And Increases Health Span Of Adult/old Mice Without Increasing Cancer Incidence (Paper)Discovery Of Potent Telomerase Activators: Unfolding New Therapeutic And Anti-aging Perspectives (Paper)The Nobel Prize in Physiology or Medicine 2009 (Website)Defy Time (Website)Telomere Benefits™ (Product Link)Mathematical Connection Between Short Telomere Induced Senescence Calculation And Mortality Rate Data (Paper)Comparison Of Telomere Length Measurement Methods (Paper)Beyond Average: Potential For Measurement Of Short Telomeres (Paper)