In 1464, with the death of Cosimo, his only surviving son, Piero di Cosimo de’ Medici – or Piero the Gouty, ‘il Gottoso’, as he came to be called – took over. He was 48 years old. He would survive - and rule - Florence for just five years. Piero was perceived to be so weak and ineffectual that long-standing friends and allies of the Medici turned against him and the family. It was a decision they would live to regret.

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