Immune discusses responses in a COVID hypervaccinated individual, synthetically glycosylated antigens for the antigen-specific suppression of established immune responses, gut bacteria–derived serotonin promotes immune tolerance in early life,

Squeezing the most killing out of neutrophils

Feb 27th, 2024 56m 58s

Immune reviews research showing that the migration of neutrophils between endothelial cells activates bactericidal function via mechanosensing. Hosts: Vincent Racaniello, Steph Langel, Cynthia Leifer, and Brianne Barker Subscribe (free): Apple

Macrophages to the rescue with Juliet Morrison

Jan 30th, 2024 1h 7m

Juliet Morrison joins Immune to discuss her career and the research of her laboratory showing that pleural macrophages translocate to the lung during infection to promote improved influenza outcomes. Hosts: Vincent Racaniello, Steph Langel, Cyn

Ang Cui unveils the cytokine symphony

Dec 28th, 2023 1h 15m

Ang Cui joins Immune to discuss her career and her work on establishing the Immune Dictionary, a compendium of single-cell transcriptomic profiles of more than 17 immune cell types in response to each of 86 cytokines (>1,400 cytokine-cell type

Germinal center dynamics with Carla Nowosad

Dec 11th, 2023 1h 11m

Carla Nowosad joins Immune to discuss her career and her work on germinal centers, the structure in secondary lymphoid tissues where B cells proliferate, differentiate, and diversify their immunoglobulin genes by somatic hypermutation. Hosts: S

Big macs

Nov 8th, 2023 1h 14m

Immune reveals the total mass (1.2kg), number (1.8 trillion), and distribution of immune cells in the human body, with macrophages contributing nearly 50% of the total cellular mass. Hosts: Vincent Racaniello, Cynthia Leifer, and Brianne Barker

After dark in the library with Ellen Rothenberg

Sep 23rd, 2023 57m 29s

From Cornell University in Ithaca New York, Vincent and Cindy meet with Ellen Rothenberg to review her career in science, starting with work on retroviruses to unraveling transcriptional networks underlying T-cell development and signaling. Hos

Can parasitic worms prevent pandemics?

Sep 8th, 2023 1h 13m

Immune explains how, in a mouse model of roundworm infection with Nippostrongylus brasiliensis, exposure to lung-migrating helminths protects mice against SARS-CoV-2 infection. Hosts: Cynthia Leifer, Stephanie Langel, and Brianne Barker Subscri

Immunology of picky eating

Jul 26th, 2023 1h 7m

Immune explains how mast cells, IgE antibody, and the brain collaborate to promote avoidance of certain foods to evade allergic responses. Hosts: Vincent Racaniello, Cynthia Leifer, and Brianne Barker Subscribe (free): Apple Podcasts, Google Po

Lung cancer and retroviruses

Jun 15th, 2023 1h 9m

Kevin joins Immune to discuss his work showing that antibodies against endogenous retroviruses promote immunotherapy of lung cancer. Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker Guest: Kevin Ng Subscribe (free): A

Sins and blessings of immunity

May 18th, 2023 1h 7m

Immune discusses immunological imprinting, also called original antigenic sin, in the context of infection with SARS-CoV-2 and influenza virus. Hosts: Vincent Racaniello, Cynthia Leifer, and Steph Langel Download Immune 66 (45 MB .mp3, 76 min)

Can T cells live forever?

May 3rd, 2023 1h 15m

Immune explains the results of a study which show that in mice, functional T cells respond to vaccination for over 10 years and 51 successive immunizations, exhibiting supernumerary cell division and longevity. Hosts: Vincent Racaniello, Cynthi

COVID-19 immune memory - what you need to know

Apr 4th, 2023 1h 30m

Immune discusses the current understanding of immune memory to SARS-CoV-2 infection and COVID-19 vaccines, which supersedes that of any other acute infectious disease. Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker

Infection infidelities with Jonathan Kagan

Feb 20th, 2023 1h 15m

Jon joins Immune to discuss the research of his laboratory on understanding how the innate immune system recognizes and responds to pathogens, and his hypothesis that infection infidelities drive innate immunity. Hosts: Vincent Racaniello, Cynt

A tangled web of wires

Jan 24th, 2023 1h 50m

Cindy, Steph, Brianne, and Vincent do a rapid review 11 immunology papers, including a wiring diagram for the immune system, group A streptococcus vaccines, systems immunology prediction of vaccines, class switch towards IgG4 after SARS-CoV-2 m

Immune, promptly

Dec 20th, 2022 1h 42m

Cindy, Steph, Brianne, and Vincent review some of their favorite immunology papers of 2022. Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email Become a patro

Immune 62: Every cell is an immune cell with De'Broski Herbert

Dec 2nd, 2022 1h 23m

De’Broski joins immune to reveal his remarkable career path and the research of his laboratory on neuroimmunology and the immune response to parasite infections. Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker Guests

Training immune cells with Julia Bohannon and Musa Mhlanga

Nov 8th, 2022 1h 4m

From SLB22 on the Island of Hawai’i, Julia and Musa join Immune to reveal their remarkable career paths, and their research on understanding trained innate immunity. Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker Gu

Immunoeducation with Sumali Pandey and Phil Mixte

Sep 22nd, 2022 1h 41m

Somali and Phil join Immune to discuss their approaches to immunology education. Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker Guest: Sumali Pandey and Phil Mixter Subscribe (free): Apple Podcasts, Google Podcasts.

Forks in the road: Th17 cells with Mandy McGeachy

Aug 19th, 2022 1h 23m

At Cornell University in Ithaca, NY, Mandy joins Immune to discuss her career and her research on understanding how Th17 cells develop and are influenced to be ‘good’ or ‘bad’ in their function. Hosts: Vincent Racaniello, Cynthia Leifer, Steph

Gut B cells awry in ulcerative colitis

Aug 3rd, 2022 1h 17m

Immune explains a study of three cohorts of patients with ulcerative colitis which finds major perturbations within the mucosal B cell compartment, highlighting a potential role for these cells in disease pathogenesis. Hosts: Vincent Racaniello

Bacteria, the new cure for wounds?

Jun 30th, 2022 1h 27m

Immune reviews data showing that in mice, skin bacteria activate keratinocytes to stimulate hair follicle regeneration and wound healing. Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker Subscribe (free): Apple Podcas

Flip flops on the thymic beach with Al Singer

Jun 1st, 2022 1h 15m

Al Singer joins immune to discuss mice that have their T cell immune system reversed, revealing the molecular basis for T cell lineage fate determination in the thymus. Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker

Cells that suck at their job

May 3rd, 2022 1h 9m

Immune reveals a CD8+ regulatory subset of T cell subset that suppress pathogenic T cells and are active in autoimmune diseases and infectious diseases including COVID-19. Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Bar

Asthma and aging

Apr 6th, 2022 1h 28m

Immune explains how aging influences chronic outcomes of respiratory viral infection through regulation of the alveolar macrophage compartment and type 2 inflammatory responses to viruse Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel,