Featuring articles on antibiotics for pneumonia in children, triple therapy for COPD, Apgar score and neonatal mortality in preterm infants, and rhythmic protein expression and the beta cell; a review article on bipolar disorder; a Clinical Problem-Solving on cryptic cachexia; and Perspective articles on four decades of HIV/AIDS; on age, complexity, and crisis; on the cost, price, and debt of medical education; and on blame.