In this episode we look at how supercomputers are used to help with managing the pandemic. It's a double-header with two guests. We start with Cineca's Andrew Emerson. As part of the EXSCALATE 4 COV EU-funded research project, he works of virtual screening of existing drugs regarding their potential efficacy against SARS-CoV-2. In part two we talk with Dan Jacobson of the Oak Ridge National Laboratory. He and his team used a big data analysis to understand how the virus "works", and they figured out very interesting mechanisms and pathways.