For patients with major depressive disorder (MDD), achieving remission is the penultimate therapeutic goal. Still, many patients treated with the standard initial treatment do not achieve a full and durable response. Rather, they are at high risk for residual and recurrent symptoms, treatment-resistance, and relapse.(1) This neuroscienceCME Chart Review activity addresses clinician-based gaps that may contribute to suboptimal rates of long-term, sustained remission among patients with MDD. Specifically, an index patient case will be used as the content foundation upon which expert faculty will engage in a provocative, consult-type exchange.