In 1920-1930’s, Dr Charles Huggins had an unusual problem: prostatic cancer cells appeared in his metabolic experiments that he was conducting on the Prostate of Dogs. With further experimentation, he was able to demonstrate that Prostate Cancer maintained its normal hormone regulation for which he was awarded the Nobel Prize for Physiology or Medicine in 1966. Prostate cancer is one of the most common male malignancies but most men will die with it rather than from it. The role of pathology is to determine how to detect this cancer and identify the clinical significance of the findings. Our interview is with Dr Bradley Webster, Histopathologist specialising in Uropathology and Lymphoid Pathology and this section of the podcast is eligible for 1 RACGP CPD point – self reporting.   This podcast also includes guest interview snippets with Dr Troye Wallet, Aged Care and Workforce General Practitioner + Health and Business Advisor.
Inherited bleeding disorders before the modern era were a death sentence. Haemophilia, also known as the Royal Disease (specifically Haemophilia B), is an X-linked coagulation disorder that the Heir to the Throne Alexei Romanov inherited in the early 1900’s. However, in 1926 a Finnish physician by the name of Erik von Willebrand identified a family with a bleeding disorder with an Autosomal Dominant pattern of inheritance. This was later named von Willebrand Disease (vWD) is now known to be the most common inherited form of bleeding disease worldwide. This podcast includes an interview with Dr Nicholas Myles regarding our current understanding of Haemophilia A, Haemophilia B, von Willebrand disease, and platelet disorders and this section of the podcast is eligible for 1 RACGP CPD point – self reporting.
The Story of Typhoid Mary An outbreak of Typhoid occurred 1906 in a wealthy family in Oyster Bay, New York. Typically a disease of ‘deprived’ people, investigators concluded that the source must have been contaminated water or freshwater clams. However, in 1907, another wealthy family in Manhattan, New York also had an outbreak. One investigator, George Soper, identified the link: it was the Cook. Mary Mallon, a.k.a. Typhoid Mary, was found to have worked for 8 different families between 1900-1907; 7 of these families experienced cases of typhoid. Mary was sent into isolation for 2 years and confirmed as a healthy carrier of the bacteria Salmonella typhi but reoffended within 3 months of release. This is the story of the villain Typhoid Mary vs the tragedy of Mary Mallon. We thank Fidelma McCorry as the voice behind the reading of Mary's letter.
Smallpox was a devastating disease described as the scourge of the world. The Variola virus was responsible for countless deaths from antiquity to the twentieth century and left most survivors with lifelong scars. Using Variolation, a primitive form of vaccination, our ancestors attempted to blunt the full force of Smallpox infections. However, it wasn’t until the twentieth century and using modern day vaccination techniques that we were able to achieve a monumental milestone and eradicate this disease. 
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Creator Details

Episode Count
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4 hours, 8 minutes
Podchaser Creator ID logo 294620