ARUK Research Fellow at Cardiff University. Her recent work has highlighted the importance of the endocytic pathway, a cellular mechanism important to recycling and maintenance of normal function, in neurodegeneration. A high proportion of the risk genes for LOAD cluster in the endocytic pathway and this is backed up by pathological evidence of endocytic dysfunction in post mortem tissue. Natalies work focuses on understanding how these genes associated to the endocytic pathway in late onset AD contribute to the molecular and cellular changes which cause the disease.