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Humane intervention points, virtual gene knockout and ex vivo brain slices for Parkinson's research

Humane intervention points, virtual gene knockout and ex vivo brain slices for Parkinson's research

Released Thursday, 16th June 2022
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Humane intervention points, virtual gene knockout and ex vivo brain slices for Parkinson's research

Humane intervention points, virtual gene knockout and ex vivo brain slices for Parkinson's research

Humane intervention points, virtual gene knockout and ex vivo brain slices for Parkinson's research

Humane intervention points, virtual gene knockout and ex vivo brain slices for Parkinson's research

Thursday, 16th June 2022
Good episode? Give it some love!
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June 2022


The papers behind the pod:


  1. Williams WO and Baneux P (2022). Humane Intervention Points: Refining endpoint terminology to incorporate non-euthanasia intervention options to improve animal welfare and preserve experimental outcomes. Laboratory Animals, in press. https://doi.org/10.1177/00236772221090801
  2. Osorio D et al. (2022). scTenifoldKnk: An efficient virtual knockout tool for gene function predictions via single-cell gene regulatory network perturbation. Patterns 3(3): e100434. https://doi.org/10.1016/j.patter.2022.100434
  3. Moudio S et al. (2022). Exposure of α-Synuclein Aggregates to Organotypic Slice Cultures Recapitulates Key Molecular Features of Parkinson's Disease. Frontiers in Neurology 13: e826102. https://doi.org/10.3389/fneur.2022.826102

 

It’s the third Thursday of June, and you’re listening to 3 Minute 3Rs, your monthly recap of efforts to replace, reduce and refine the use of animals in research. Follow this link for the full transcript:

https://nc3rs.org.uk/3-minute-3rs-podcast-june-2022-transcript


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