The frequency of hematospermia in transgender women is unknown, indicating a gap in current medical understanding. Join medical experts Tamar Reisman, MD, Clinical Endocrinologist at New York Presbyterian Weill Cornell Medical Center, and Sina Jasim, MD, MPH, ACCR Editor-in-Chiefand Associate Professor of Medicine at Washington University School of Medicine, as they delve into a groundbreaking clinical case report titled "Hematospermia in a Transgender Woman with Evidence for Endometrial Tissue in the Prostate." Tune in as they discuss the highlights of the case, when to screen for endometriosis or ectopic Müllerian epithelial tissue growth in transgender women undergoing feminizing gender-affirming hormone therapy, and how to address challenges and barriers to patient care. View the full report in the Jan. 2024 issue of ACCR at https://doi.org/10.1016/j.aace.2024.01.006.