In the third episode of the ACE podcast, editors Rick Dutton, M.D., M.B.A., Stacy Jones, M.D., and Joel Johnson, M.D., Ph.D., return for an inside look at the production of the 15B issue launching in October 2018. The editors share anecdotes of events that sparked ideas for ACE content, including ethical conundrums regarding organ donation and informed consent, and why certain “lima bean” topics such as statistics found their way into this issue of ACE. The editors also discuss their methods for ensuring the accuracy of ACE content, choosing and creating illustrations, and keeping content fresh for long-time ACE readers.