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Episode 3 S1: Risk factors associated with increasing the risk of developing food allergy

Episode 3 S1: Risk factors associated with increasing the risk of developing food allergy

Released Sunday, 21st March 2021
Good episode? Give it some love!
Episode 3 S1: Risk factors associated with increasing the risk of developing food allergy

Episode 3 S1: Risk factors associated with increasing the risk of developing food allergy

Episode 3 S1: Risk factors associated with increasing the risk of developing food allergy

Episode 3 S1: Risk factors associated with increasing the risk of developing food allergy

Sunday, 21st March 2021
Good episode? Give it some love!
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Welcome back to episode 3. Numerous risk factors have been proposed to contribute to food allergy or sensitization, in this episode, I will address a few of the most researched genetic and environmental risk factors that increase the risk of developing IgE-mediated food allergy. If you would like to find out more please do visit my blog post which will detail everything that was discussed in the podcast. You can find the blog post based on this podcast on my website under blogs.

Disclaimer:
The information in this podcast is for information and entertainment purposes only.
I am not a medical professional so I have never and will never give medical advice. You should always speak to a health care provider about your unique health needs. My opinions are entirely my own. I only discuss published literature in this podcast. I am not responsible for any claims related to the procedures, professionals, products or methods discussed in the podcast, and do does not approve or endorse any products, professionals, services or methods that may be referenced to in this podcast.


Instagram: @AllergieswithAyah
Website: https://allergieswithayah.wixsite.com/website

Image description: The image is an infographic, with a light green background. There is a cartoon mustard tub, celery stick and different types of nuts at the bottom left corner. At the bottom right corner there is a cartoon image of a glass of wine, milk carton, tofu, shellfish, crustacean, purple fish and one egg. On the top left corner there are three wheat stalks and sesame and lupin seeds as cartoon images. On the top right there is a logo with a green antibody in a white box. The logo has the words Allergies at the top of the antibody, the word with to the centre left of the antibody and the word Ayah to the centre right of the antibody. At the centre top of the infographic there is the words Allergies with Ayah in written in grey. The word episode 2 is written to the centre left of Ayah’s face. In the centre of the image there is a cartoon character depiction of Ayah. Ayah has brown long hair and is smiling. Ayah’s hand is together in two fists and she is wearing a purple top

Reference list
Allen, K.J., Koplin, J.J., Ponsonby, A.L., Gurrin, L.C., Wake, M., Vuillermin, P., Martin, P., Matheson, M., Lowe, A., Robinson, M. and Tey, D., (2013). Vitamin D insufficiency is associated with challenge-proven food allergy in infants. Journal of allergy and clinical immunology, 131(4), pp.1109-1116.

Asai, Y., Eslami, A., van Ginkel, C.D., Akhabir, L., Wan, M., Ellis, G., Ben-Shoshan, M., Martino, D., Ferreira, M.A., Allen, K. and Mazer, B., (2018a). Genome-wide association study and meta-analysis in multiple populations identifies new loci for peanut allergy and establishes C11orf30/EMSY as a genetic risk factor for food allergy. Journal of Allergy and Clinical Immunology, 141(3), pp.991-1001.

Asai, Y., Eslami, A., Van Ginkel, C.D., Akhabir, L., Wan, M., Yin, D., Ellis, G., Ben-Shoshan, M., Marenholz, I., Martino, D. and Ferreira, M.A., (2018b). A Canadian genome-wide association study and meta-analysis confirm HLA as a risk factor for peanut allergy independent of asthma. Journal of Allergy and Clinical Immunology, 141(4), pp.1513-1516.

Chalmers JR, Haines RH, Mitchell EJ, Thomas KS, Brown SJ, Ridd M, et al. Effectiveness and cost-effectiveness of daily all-over-body application of emollient during the first year of life for preventing atopic eczema in high-risk children (The BEEP trial): protocol for a randomised controlled trial. Trials 2017;18:343.

Crespo JF, James JM, Fernandez-Rodriguez C, Rodriguez J. Food Allergy: Nuts and Tree Nuts. Br J Nutr. 2006;96 2:S95–102.

Feeney, M., Du Toit, G., Roberts, G., Sayre, P.H., Lawson, K., Bahnson, H.T., Sever, M.L., Radulovic, S., Plaut, M., Lack, G. and Chan, S., 2016. Impact of peanut consumption in the LEAP study: feasibility, growth, and nutrition. Journal of Allergy and Clinical Immunology, 138(4), pp.1108-1118.

Grimshaw, K. E., Bryant, T., Oliver, E. M., Martin, J., Maskell, J., Kemp, T., Clare Mills, E. N., Foote, K. D., Margetts, B. M., Beyer, K., & Roberts, G. (2016). Incidence and risk factors for food hypersensitivity in UK infants: results from a birth cohort study. Clinical and translational allergy, 6, 1. https://doi.org/10.1186/s13601-016-0089-8

Lack, G., 2008. Epidemiologic risks for food allergy. Journal of Allergy and Clinical Immunology, 121(6), pp.1331-1336.

Marenholz, I., Grosche, S., Kalb, B., Rüschendorf, F., Blümchen, K., Schlags, R., Harandi, N., Price, M., Hansen, G. & Seidenberg, J. (2017). 'Genome-wide association study identifies the SERPINB gene cluster as a susceptibility locus for food allergy', Nature communications, 8(1), pp. 1-10.

Matsui, T., Tanaka, K., Yamashita, H., Saneyasu, K.-i., Tanaka, H., Takasato, Y., Sugiura, S., Inagaki, N. & Ito, K. (2019). 'Food allergy is linked to season of birth, sun exposure, and vitamin D deficiency', Allergology International, 68(2), pp. 172-177.

Perkin MR, Logan K, Marrs T, Radulovic S, Craven J, Flohr C, et al. Enquiring About Tolerance (EAT) study: feasibility of an early allergenic food introduction regimen. J Allergy Clin Immunol 2016a 137:1477-86.

Perkin MR, Logan K, Tseng A, Raji B, Ayis S, Peacock J, et al. Randomized trial of introduction of allergenic foods in breast-fed infants. N Engl J Med 2016b ;374: 1733-43.

Perkin, M.R., Logan, K., Marrs, T., Radulovic, S., Craven, J., Boyle, R.J., Chalmers, J.R., Williams, H.C., Versteeg, S.A., Van Ree, R. and Lack, G., 2021. Association of frequent moisturizer use in early infancy with the development of food allergy. Journal of Allergy and Clinical Immunology, 147(3), pp.967-976.

Savilahti, E. M., Ilonen, J., Kiviniemi, M., Saarinen, K. M., Vaarala, O. & Savilahti, E. (2010). 'Human leukocyte antigen (DR1)-DQB1* 0501 and (DR15)-DQB1* 0602 haplotypes are associated with humoral responses to early food allergens in children',International archives of allergy and immunology,152(2), pp. 169-177.si

Schoemaker, A. A., Sprikkelman, A. B., Grimshaw, K. E., Roberts, G., Grabenhenrich, L., Rosenfeld, L., Siegert, S., Dubakiene, R., Rudzeviciene, O. & Reche, M. (2015). 'Incidence and natural history of challenge‐proven cow's milk allergy in European children–EuroPrevall birth cohort',Allergy,70(8), pp. 963-972.

Sicherer, S. H., Furlong, T. J., Maes, H. H., Desnick, R. J., Sampson, H. A. & Gelb, B. D. (2000). 'Genetics of peanut allergy: a twin study',Journal of Allergy and Clinical Immunology,106(1), pp. 53-56.

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Venkataraman, Devasmitha et al. “Filaggrin loss-of-function mutations are associated with food allergy in childhood and adolescence.” The Journal of allergy and clinical immunology vol. 134,4 (2014): 876-882.e4. doi:10.1016/j.jaci.2014.07.033

Visscher, P.M., Wray, N.R., Zhang, Q., Sklar, P., McCarthy, M.I., Brown, M.A. and Yang, J., (2017). 10 years of GWAS discovery: biology, function, and translation.The American Journal of Human Genetics,101(1), pp.5-22.

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From The Podcast

Allergies with Ayah

Hello and welcome to Allergies with Ayah a podcast all about food allergies and other food hypersensitivities. Growing up with food allergies, being a food allergy awareness advocate, studying and researching food allergies and now working in the food hypersensitivity field and getting to interact with world leading researchers and experts I have developed a passion for understanding all aspects of food allergy and other food hypersensitivities!In this podcast we will be taking a closer look at some of the current trends in food hypersensitivity published research and dissect some of the misinformation we often read or hear about, we will also hear stories and advice from people with lived experience. My aim to create a scientifically curious community and to get you interested in the science behind food allergies and other hypersensitivities. Instagram: @AllergieswithAyah Website: https://allergieswithayah.wixsite.com/website.Disclaimer:The information in this podcast is for information and entertainment purposes only.I am not a medical professional so I have never and will never give medical advice. You should always speak to a health care provider about your unique health needs. My opinions are entirely my own. I only discuss published literature in this podcast. I am not responsible for any claims related to the procedures, professionals, products or methods discussed in the podcast, and do does not approve or endorse any products, professionals, services or methods that may be referenced to in this podcast. Image description: The image is an infographic, with a light green background. There is a cartoon mustard tub, celery stick and different types of nuts at the bottom left corner. At the bottom right corner there is a cartoon image of a glass of wine, milk carton, tofu, shellfish, crustacean, purple fish and one egg. On the top left corner there are three wheat stalks and sesame and lupin seeds as cartoon images. On the top right there is a logo with a green antibody in a white box. The logo has the words Allergies at the top of the antibody, the word with to the centre left of the antibody and the word Ayah to the centre right of the antibody. At the centre top of the infographic there is the words Allergies with Ayah in written in grey. The word episode 1 is written to the centre left of Ayah’s face. In the centre of the image there is a cartoon character depiction of Ayah. Ayah has brown long hair and is smiling. Ayah’s hand is together in two fists and she is wearing a purple top.

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