In which our heroes discuss the impending doom coming from Wuhan. Also wtf FDA re SRPT?00:40 - We survived JPM!05:00 - Are we all going to die form Coronavirus?22:43 - The Goop series on Netflix26:22 - Amarin has the one oil to rule them al

47: The amyloid hypothesis will outlive all of us.

Oct 23rd, 2019 36m 10s

In which we welcome our new commentator Wiktoria, and discuss the new BIIB shuck and jive.

46: The interesting Relmada data in depression and some balance sheet disasters

Oct 17th, 2019 50m 31s

Discuss the recent Relmada data, Geovax, Amyris, WeWork and more:01:15: RLMD data in TRD13:23 The GOVX disaster18:52 WeWork is being flushed down the toilet24:08 Will HR3 passage actually mean fewer drugs will be developed?29:49 Don't

45: The hysteria around vaping and does Purdue really deserve to go bankrupt?

Oct 9th, 2019 52m 31s

People need some perspective on vaping and these opioid lawsuit liabilities are out of control and will hurt patients. Here is a table of contents:1:08 The hysteria around vaping14:44 A new penile traction device for Peyronie's16:38 Does

44: FDA has its hands full with Novartis, Amarin and people drinking bleach

Aug 15th, 2019 42m 12s

Novartis gives the FDA a headache, the FDA then gives Amarin a headache and people are trying to cure their problems with bleach.00:42 Novartis cheated18:47 There are two FDA's, one for AMRN and another for everyone else30:00 Don't drink bl

43: Interview with Thomas Meyer, CEO of Auris Medical

Aug 5th, 2019 39m 4s

We discuss Auris Medical’s development programs for intranasal betahistine for acute vertigo as well as to treat some of the major side effects of antipsychotic medication.01:07 Auris’s AM-125 program for acute vertigo16:57 The Phase II trial

42: Interview with Stephane Piat, CEO of Carmat

Jul 29th, 2019 40m 35s

We discuss Carmat's total artificial heart, the technology, approval pathways and commercial potential00:42 Carmat’s total artificial heart, the history and the technology08:54 The data so far18:00 The coming technological advances20:49

41: On vomit boat trials and Elon Musk

Jul 22nd, 2019 23m 29s

Why would anyone sign up for a vomit boat trial or get thousands of electrodes implanted into their brains?00:41 The VNDA vomit boat trial09:14 More on the KPTI approval11:52 Elon Musk's Neuralink18:44 Netflix has peaked

40: Interview with Daniel Schneider, CEO of Photocure

Jul 16th, 2019 39m 23s

We cover Photocure’s marketed bladder cancer diagnostic product Hexvix/Cysview, its data and potential for growth in the United States and the prospects for future competition.01:03 – What does Photocure do?13:49 – How do the US and EU market

39: Biotech, a magical land of mystery

Jul 11th, 2019 44m

Why did selinexor get approved? What's going on with Roche/Spark? Why did ITCI have crazy results? Also a farewell.00:37 Michael Becker RIP02:22 What's up with the $KPTI approval14:19 Some confusing $ITCI data23:21 Why is the FTC takin

38: Vyleesi, of house Palatin, second of its kind, and mother of scams

Jul 1st, 2019 48m 13s

Also ABBV buys a company, and why academia sucks.00:30 - Vyleesi is the worst drug ever approved23:27 - Abbvie buys Allergan32:30 - Twitter censors tesladeaths.com34:14 - CRISPR babies in Russia?37:39 - Nat has a theory40:47 - The cabal r

37: Cymabay's NASH disaster and some financings that burned investors

Jun 24th, 2019 53m 5s

Can anyone really beat diet and exercise for NASH? Also, buyer beware. Here is some more detail on what we talk about:00:39 Cymabay's disastrous NASH data, you're really better off with diet and exercise17:25 Ampion screws some investors

36: KRAS for cancer and Enbrel for Alzheimer's

Jun 10th, 2019 42m 54s

00:37 KRAS a hit at ASCO08:59 Enbrel for Alzheimer's?20:49 You don't need to take 10,000 steps a day24:58 Satanic messages from Google Translate27:30 What is up with the ARK model on TSLA?31:07 Gamestop has a really bad quarter35:09

35: Interview with Yuval Cohen, CEO of Corbus Pharmaceuticals

May 20th, 2019 40m 51s

An interview of Yuval Cohen, CEO of Corbus Pharmaceuticals where we discuss the cannabinoid space as well as the Corbus pipeline

34: Getting figged by Ovid and Cytokine

May 13th, 2019 39m 1s

Another what's wrong with people sort of episode:01:00 CYTK fails in Phase II but moves forward anyway06:40 OVID insults analysts18:42 Figging. Why?24:05 MNK bribes doctors28:35 TSLA and Peloton

33: Moleculin be swindlin?

Apr 29th, 2019 38m 27s

Also we bid farewell to Briana.02:05 Was the MBRX pump on purpose?06:17 TSLA lost 4 board members on Good Friday12:52 AMRS was in default for a day, also announced on Good Friday17:00 Macro/financial system stuff27:22 The IQVIA report

32: An ode to animal research; ZGNX and Planet of the Apes

Apr 15th, 2019 44m 56s

Also the trajectory of GILD and eyes full of bees.00:43 Refusal to file letter for ZGNX14:30 Weirdness with AMRS27:00 Chinese scientists give human intelligence genes to monkeys34:48 Bees living off of a woman's tears36:48 GILD has layo

31: Biogen blows it big time

Mar 25th, 2019 50m 16s

On the Sisyphean struggle that is the amyloid hypothesis. Also, space herpes.00:28 Biogen blows up21:00 Should Biogen buy Sage?33:10 Another nutritional cohort study42:55 Space herpes (watch out Elon Musk)

30: Gottlieb will always be my sugar loaf

Mar 18th, 2019 47m 47s

In which our heroes discuss Scott Gottlieb leaving, the new Theranos movie, and the risks of cutting sugar loaf.01:02 Scott Gottlieb is leaving the FDA10:35 The Inventor documentary on Theranos18:00 College bribery admissions scandal27:4

29: ONCE in a lifetime, same as it ever was

Mar 4th, 2019 39m 52s

In which our heroes discuss Roche's motivations with Spark. Also musings on senate subcommittees and goat wine.00:43 Spark gets bought04:40 Senate drug pricing hearing16:22 The ER is an interesting place24:13 Karyopharm's panel29:19 B

28: Intercept gives investors a taste of bile

Feb 25th, 2019 39m 25s

Another NASH drug disappoints and three biotechs declare bankruptcy:00:35 Intercept's NASH drug has some questionable data15:45 Immune Pharma, Aradigm and Pernix declare bankruptcy24:10 Ambrosia gets a warning from the FDA35:15 Why woul

27: Did Gilead just prove the null hypothesis?

Feb 18th, 2019 50m 33s

GILD messes up in NASH while OMER cult members buy a bill of goods.00:55 GILD fails in NASH, badly11:54 Who is OMER kidding?17:41 A Harvard geneticist claims to have found a Fountain of Youth supplement21:21 Brain buzzing headphones for los

26: A shambolic week

Feb 11th, 2019 41m 18s

Solid slips and Pain Therapeutics loses it. Also light bulbs for your ears and why Nat hates doctors:01:00 SLDB not so solid02:56 PTIE attacks FDA08:50 VNDA goes PETA11:56 Nat hates doctors16:33 Shining a light into ears to treat jet lag2

25: Cancer cure-alls, Alzheimer's vaccines and other nonsense

Feb 4th, 2019 34m 55s

Here is what we talk about:00:30 Baby, it's cold outside04:15 BIIB Fight Club: they won't talk about interim analyses06:31 TYME debacle09:57 A cure for all cancers?14:08 Selling "young" blood16:30 An Alzheimer's vaccine company sta

24: NWBO > SGYP

Dec 17th, 2018 43m 4s

You can jump out of a plane without a parachute but don’t use tap water with your neti pot:00:46 A study shows that parachutes do not lower mortality when jumping out of a plane06:27 Swans belong to the Queen14:30 NWBO > SGYP20:30 Lanne