Prof. Wei Chen of Northwestern University is a pillar of the ASME design automation and design engineering communities and an exceptionally prolific contributor to the science of engineering design since obtaining her PhD in 1995. This AMR audio interview reflects on her long record of professional service, most recently as Editor of the Journal of Mechanical Design, and her perspectives on the power of interdisciplinary collaboration in promoting advances in predictive science, the integration of design in undergraduate engineering curricula, and how consumer choice may be influenced by purposeful design.