Ed Piskor has been cartooning professionally in print form since 2005, starting off drawing American Splendor comics written by Harvey Pekar. The duo continued working together on 2 graphic novels, Macedonia, and The Beats. Ed began self-publishing Wizzywig after developing a huge interest in the history of Hacking and Phone Phreaking. 3 volumes, making up 3/4 of the full story, have been published to date.

Recently Ed has designed the characters for the new Adult Swim series, Mongo Wrestling Alliance.