What is the function of the vitamin D receptor (VDR)? How does it interplay with the retinoid receptor (RXR)? What happens to your thyroid function when you supplement D3 and drive up your 1,25D levels? Can supplementing D3 drive the development of osteoporosis? Why does the half-life of 25D and 1,25D matter? Why do you never hear the word "heterodimerization" in vitamin D smurf talk? What is a dimer?  Vitamin D researcher Jim Stephenson Jr shares his research and dot connections about hormone D supplementing and the effects that it has to cause imbalance in our body. He challenges listeners to dig deeper beyond two or three molecules and to realize the complexity of secosteroid hormone D. We go down the list point-by-point of a popular pro vitamin D3 article written by researcher Danny Roddy with the goal of bringing clarity to the discussion. We cover oral versus topical administration of D3 and explore the question: how would a substrate lower one of the potentials that it can become?  Jim's Facebook group: https://www.facebook.com/groups/517807781731760 The pro D3 supplement article: https://dannyroddy.substack.com/p/vitamin-d-bioenergetic-wunderkind The Man Who Sold America On Vitamin D — And Profited In The Process https://khn.org/news/how-michael-holick-sold-america-on-vitamin-d-and-profited/ Dr Hollick’s Vitamin D supplement: https://shopee.ph/FERN-D❤%EF%B8%8F-Your-DAILY-SUNSHINE-VITAMINS-i.110227573.2088103398 The renin–angiotensin–aldosterone system and calcium-regulatory hormones  https://www.nature.com/articles/jhh2014125.pdf?origin=ppub Low vitamin D levels do not aggravate COVID-19 risk or death, and vitamin D supplementation does not improve outcomes in hospitalized patients with COVID-19: a meta-analysis and GRADE assessment of cohort studies and RCTs https://nutritionj.biomedcentral.com/articles/10.1186/s12937-021-00744-y?fbclid=IwAR0iC-NWzVOXsX3PQfqpa-zXYuQqvUZwUmwP-ymNwhT4XLU46ovYimbU_VA Characterization of a new pathway that activates lumisterol in vivo to biologically active hydroxylumisterols https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595834/?fbclid=IwAR3vuqTiEt7LlGDA4JKBWNiy84vUQH1kMrjZR7bkragBW_j9NYDfZ-lQv5M Vitamin D4 in Mushrooms https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3411670/?fbclid=IwAR3VA9RAwSVm5eLT_Vh1PSZBgf1sqOWb-TyZ-hRWELNEaokTh6aRRkOhs98 Photobiology of Vitamin D in mushrooms and its bioavailability in humans https://pubmed.ncbi.nlm.nih.gov/24494050/ Trevor Marshall PhD published research: https://www.trevormarshall.com/papers.htm Steroid Hormone Vitamin D: Implications for Cardiovascular Disease https://pubmed.ncbi.nlm.nih.gov/29798901/ 25-Hydroxylation of vitamin D3: relation to circulating vitamin D3 under various input conditions https://pubmed.ncbi.nlm.nih.gov/18541563/ Vitamin D in Mushrooms https://www.ars.usda.gov/ARSUserFiles/80400525/Articles/AICR09_Mushroom_VitD.pdf Absence of Seasonal Variation in Serum Concentrations of 1,25-Dihydroxyvitamin D Despite a Rise in 25-Hydroxyvitamin D in Summer https://academic.oup.com/jcem/article-abstract/53/1/139/2677695?redirectedFrom=fulltext&fbclid=IwAR2zY9zb43zc66cLY6b50zbhtbCOThYN-CRw2K8YK5LwSm8xeGm5mqM7zdQ Vitamin D: the alternative hypothesis http://autoimmunityresearch.org/transcripts/AR-Albert-VitD.pdf My website: www.matt-blackburn.com Mitolife products: www.mitolife.co