Robert Klein, DPM and Cathy Milne, MSN, APRN, CWOCN-AP evaluate the science, evidence and wound healing efficacy of oxidized regenerated cellulose (ORC)/collagen, negative pressure wound therapy and hybrid drapes, review wound types that would benefit from the use of a new indication utilizing a collagen matrix with oxidized regenerated cellulose (ORC) and Silver under Negative Pressure Wound Therapy (NPWT) paired with a silicone drape and explore, via illustrative case studies, clinical outcomes from the combines use of NPWT, ORC Collagen, hybrid drapes and advanced wound care technologies.