Britt M. Meyer, PhD, RN, CRNI®, VA-BC, NE-BC and Stephen Rowley, BSc (Hons) MSc identify common barriers with traditional negative pressure wound therapy use, correlate early use of negative pressure wound therapy with instillation on improved patient outcomes, explore innovations in NPWTi-d designed for automated and efficient patient care and examine, via real-world techniques, tips and tricks to optimize use of NPWTid.