The podcast which got me to start taking my career seriously. Allen, Joe, and Michael have (combined) decades of experience, and it comes across in their discussions of algorithms, data structures, and the classics of our industry.
They have a great chemistry (since they've been friends for so long), and they approach even the most difficult topics with humour and care.
And don't let the ".NET" part of the title put you off. Whilst the show started with a speciality in .NET, it is more of a discussion of development topics with very little that is specific to .NET.