On a snowy January day in 2022, Dr. Muhammad Mohiuddin, director of cardiac xenotransplantation at the University of Maryland School of Medicine, oversaw the first transplantation of a pig heart into a human body. Dr. Mohiuddin joins Justin to discuss this landmark procedure—from the selection of patient David Bennett to the complications that ultimately led to the transplanted heart’s failure 60 days after the successful surgery—and what comes next for this rapidly advancing field.

Dr. Mohiuddin describes the next ideal xenotransplant recipient and explains how drug companies can support the field. Plus, Justin and Dr. Mohiuddin examine how xenotransplantation has evolved over the past 30 years and why on-demand organs may be closer to reality than science fiction.

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