This episode is about the TDM of anticancer therapies, a space where there is a sense of frustration about body-size based dosing, but while concentration-based promises to make a difference to clinical care, it still feels that progress has been less than satisfying. Florian opens the episode with an ode to oncologists, a song from the heart to say: ‘We can work it out!’  

Our guests today are Dirk Jan Moes and Vikram Gota, both very active in ‘working things out’ in the space, in different corners of the world. We unpack the many challenges but arrive at the conclusion that for TDM in oncology, ‘the future is bright!’

In this episode we hear about:

• Older anticancer drugs: can we do new tricks with old drugs, or have we missed the boat?
• The importance of the drug label and reimbursement for clinical implementation
• Anticancer drugs and clinical contexts where microsampling can enhance implementation
• Financial toxicity: should we be styling ourselves as financial toxicologists!?
• Progress in the paediatric space
• Combining  concentration measurement with pharmacogenetics, biomarkers and model informed precision dosing
• Buy-in: the importance of clinical champions and education initiatives

Eight Drugs a Week is supported by the International Association of Therapeutic Drug Monitoring and Clinical Toxicology (IATDMCT). The personal views of the hosts and guests do not necessarily reflect the position of the Association. 

To join IATDMCT, visit https://www.iatdmct.org/member-join 

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About our guests: 

Dirk Jan Moes is a Laboratory Hospital Pharmacist and Clinical Pharmacologist, Assistant Professor of Applied Clinical Pharmacometrics at the Department of Clinical Pharmacy and Toxicology at the Leiden University Medical Centre in The Netherlands. 

Vikram Gota is an MD, Professor & Officer-in-charge of the Department of Clinical Pharmacology at the Advanced Centre for Treatment Research & Education in Cancer at the Tate Memorial Centre in Mumbai, India.