During his final year of his oncology fellowship at Northwestern, Suneel Kamath, MD, was finally getting used to telling people that he treats cancer for a living. He has perfected the art of letting people know that it is 'not as depressing as they think' and that there is much joy, even laughter, in his work as an oncologist. In this audio essay, he shares his experience with laughter and medicine. A version of this essay was first published in the Journal of Clinical Oncology.