Migraine is a severe neurological disorder that affects a significant proportion of the population. Prevalence estimates vary between 12 and 25% depending on the population studied. The disorder has a significant genetic component. In this interview, Andrew Whitfield-Cook interviews Professor Lyn Griffiths on her very promising research which looks at genetic profiling in conjunction with nutriceutical therapies. These clinical trial highlight the potential importance of nutritional interventions in this disorder.