Dr Claire Palles studies whole genome sequencing data and targeted analyses with the aim of discovering genetic variants that affect susceptibility to colorectal cancer and Barrett’s oesophagus. The gastrointestinal track is responsible for mor

Rare neurological disorders

Feb 4th, 2016 8m 44s

Chorea-Acanthocytosis: ChAc is a rare progressive neurological disorder caused by mutations in a very complex gene. Dr Antonio Velayos-Baeza is interested in two main projects: Chorea-acanthocytosis (ChAc), a rare autosomal-recessive disorder t

Computation and genetics

Jan 7th, 2016 4m 25s

Resistance to drugs in bacteria can be aquired by swapping genes between individual bacteria. Computer programs developed by Dr Iqbal enable doctors to predict which antibiotics will be met with drug resistance, enabling the selection of the ri

The Evolution of the Genome

Dec 2nd, 2015 5m 54s

Computational and stastistical methods help us understand evolution as well as genetic disease. Professor Gerton Lunter is interested in investigating the processes of evolution and biology using computational methods. His focus is on sequencin

DNA replication and Cancer

Dec 10th, 2014 7m 5s

DNA replication and Cancer The process of DNA replication is complex, and mistakes can lead to genome instability. Surveillance systems are not always successful which results in mutations that have the potential to inactivate genes or change t

Big Data

Dec 10th, 2014 6m 19s

Over the past decade, data-driven science has produced enormous sets of data. The convergence of statistics and computer science, in the field known as machine learning, provide the means to understand these large datasets. Ultimately, machine

Human Genetics

Jul 9th, 2013 5m 55s

Professor Peter Donnelly tells us how genetics helps us to understand common diseases and develop new drugs. Understanding which variations in our DNA affect susceptibility to diseases can provide new insights into the disease process and lead

Psychiatric Genetics

May 21st, 2013 4m 28s

Every psychiatric disorder has a genetic contribution. Although anxiety and depression are very common diseases, current treatments are not very good. A better understanding of the contribution of genetic variants might help us better diagnose

Statistical Genetics

May 17th, 2012 7m 24s

Professor Gil McVean tells us how statistical genetics helps us understand and treat disease. Genomic technology and statistical analysis of the genome is a powerful tool in understanding disease. Prof Gil McVean is the Head of Bioinformatics a

Specific Language Impairment

Nov 14th, 2011 4m 2s

Dr Dianne Newbury talks about the contribution of genetics to specific language impairment. Specific Language Impairment (SLI) is a complex genetic disorder in the development of language. Dr Dianne Newbury is looking for the genes that predisp

Dyslexia and Genetics

Sep 27th, 2011 7m 5s

Dr Silvia Paracchini talks about the influence of genetics in dyslexia. Dyslexia is a reading impairment that effects up to 10% of children. Dr Silvia Paracchini aims to identify the genetic components of dyslexia to better understand its under

Obesity and Genetics

Mar 29th, 2011 8m 3s

Dr Cecilia Lindgren explores the links between obesity and genetics. Obesity and its consequences are major and growing challenges for health care providers worldwide. While lifestyle is a contributor, over 30 genes associated with body mass in

Genetic Variation in Inflammation and Immunity

Nov 29th, 2010 5m 16s

Dr Julian Knight explains how genetic variants modulate gene expression and influence the susceptibility to commom diseases. Genetic variation plays an important role in individual susceptibility to common diseases. Dr Julian Knight's research

Chromatin Remodelling

Nov 15th, 2010 4m 57s

Dr Erika Mancini explains the role of chromatin in the regulation of gene transcription. Chromatin, the physical packaging of DNA within the nucleus, plays an important role in the regulation of gene expression. All our cells contain the same

Women's Health

Sep 30th, 2010 6m 32s

Dr Krina Zondervan talks about endometriosis, an incapacitating women's health condition. Endometriosis is a gynaecological condition, which often causes severe pelvic pain and may lead to infertility. In women suffering from endometriosis, cel

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