Hailed as the father of the biotechnology industry, the technologist and entrepreneur George Rathmann was the founding CEO of Amgen Inc. A chemist with a Ph.D. from Princeton, he worked for 21 years at 3M, where he helped develop Scotchgard, among other products. In 1980, he left a secure job as head of diagnostic research at Abbott Laboratories to become CEO of Amgen Inc., an underfunded start-up seeking to develop new drugs by splicing DNA from one organism into the genome of another. Rathmann led the company through a record-setting public offering, and introduced the revolutionary drug Epogen, now an essential component of therapy for kidney disease. George Rathmannn retired from Amgen in 1990, to find Icos Corporation. At Icos, he oversaw the development of another breakthrough drug, Cialis, for the treatment of erectile dysfunction. Ten years later Rathmann led a third biotech startup, Hyseq, to explore the application of gene-based therapeutics to cardiovascular disease, cancer and other conditions. The same year, he addressed the Academy of Achievement at its 2000 gathering in Scottsdale, Arizona. In this podcast, recorded on that occasion, Dr. Rathmann recalls his career in science and business, and reflects on the ethical responsibilities of this dual career path.