In 2014, Hamilton Perkins founded Hamilton Perkins Collection, an independent brand that designs and produces unique and award-winning bags and accessories made from recycled materials. Each bag is made from recycled plastic water bottles, billboard vinyl, pineapple leaf fiber, upcycled fabric banners, and other advertising waste.

Perkins was the winner of the Virginia Velocity Tour hosted by the Governor of Virginia. The non-profit B Lab honored Hamilton Perkins Collection as a "Best for the World Overall" B Corporation in 2017. Perkins was voted to Inside Business’ 40 under 40 and Old Dominion University Alumni Association’s 40 under 40 lists.

Perkins has been mentioned in Forbes, Fast Company, The New York Times, Money Magazine, and The Washington Post. Select past client work includes Hewlett-Packard, Nordstrom, Target, Dow Chemical, Oracle, Salesforce, Barnes and Noble, West Elm, Holt Renfrew, Salesforce, C.F. Martin & Company, Imerys, Leesa Sleep, Zappos, Paramount Pictures, and Ellen.

The brand is currently offered in nearly 150 leading department stores and specialty stores in the United States, Canada, and Europe. Hamilton Perkins Collection’s e-commerce store is available at hamiltonperkins.com.

Perkins serves on the executive advisory council board at Old Dominion University’s Strome College of Business.