Humans have had an insatiable appetite for inhibiting production of prostaglandins for centuries! This series delves into the history of aspirin and NSAIDs, looking at the understanding of the prostaglandin pathway.

·       Intro 0:12

·       In this episode 0:23

·       What are NSAIDs? 0:53

·       Prostaglandins 5:50

·       What are prostaglandins? 7:19

·       Where do prostaglandins come from? 8:45

·       So, what do we do with prostaglandins? 13:15

·       How did they figure out prostaglandins? 13:55

·       Naming the prostaglandin 21:25

·       Phospholipids 24:46

·       Arachidonic acid 25:28

·       Arachidonic acid into prostaglandins: how do you prove it? 26:32

·       How does arachidonic acid turn into prostaglandins? 27:27

·       Cyclo-oxygenase 28:36

·       mRNA and COX-2 32:50

·       On the next episode 35:55

·       Summary 36:38

·       Thanks for listening 37:49

Disclosures: Brown reports no relevant financial disclosures.

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References:

Botting RM. Pharmacol Rep. 2010;doi:10.1016/s1734-1140(10)70308-x.

Flower RJ. Br J Pharmacol. 2006;doi:10.1038/sj.bjp.0706506.

Flower RJ. Br J Pharmacol. 2019;doi:10.1111/bph.14588.

Kurzrok R, et al. Exp Biol Med. 1930;doi:10.3181/00379727-28-5265.

https://www.nobelprize.org/prizes/medicine/1970/euler/biographical/.

von Euler US. J Physiol. 1936;doi:10.1113/jphysiol.1936.sp003433.