Unprecedented progress has been made in recent years in the field of hemophilia care, advancing capabilities to tailor treatment to the needs of each patient. In this episode of Hemcast, Dr Ian Winburn explores “Hemophilia Care in 2021” with global experts Dr Cedric Hermans, Dr Gerry Dolan, and Dr Keith Gomez. Together, they provide thought-provoking insights into the current state of hemophilia care, highlight important considerations for the management of hemophilia within the intensive care unit, and discuss the possible impact of “big data” on precision medicine and hemophilia.