Dr. Sheldon Glashow, former Harvard professor of physics, begins by describing his fascination with science as a kid.  He then explains how he came up with the ideas and paper that won his Nobel prize.  Amazingly, Dr. Glashow wrote the paper just after graduate school.  He explains some of his subsequent research, including theoretically introducing the existence of a fourth quark, the charmed quark.  Dr. Glashow then discusses continuing controversies and settled ones in physics, the weak state of scientific knowledge, even among Harvard students outside science, and the unfortunate politicization of science and scholarship in general.

Also see: https://www.nobelprize.org/prizes/physics/1979/glashow/biographical/