This episode discusses four MMWR reports. First, teens report that seeking relief from stress, anxiety, and depression are top reasons for substance use. Second, antimicrobial resistance prompts CDC to update guidance on antibiotic selection to prevent meningococcal disease. Third, among workers in the oil and gas extraction industry, well-servicing contractors were found to be at the highest risk of severe injury. Finally, 8 mg naloxone was associated with more withdrawal symptoms when used during an overdose.