This episode discusses three MMWR reports. First, seven children in Utah were hospitalized with E. coli after drinking and playing in untreated water used for watering yards. Second, traveling in malaria-endemic countries can increase travel-associated malaria in the U.S. Prompt identification, diagnosis, and treatment are essential to prevent severe illness. Last, highly drug-resistant infections were identified in U.S. patients who recently traveled to Mexico for stem cell injections.