Charles Willis was raised in Fort Worth, TX, where by the 8th grade he had made a determination that he wanted to become a doctor. After graduating from Texas Christian University (TCU), Charles would attend medical school at the University of Texas Health Center, and a post-doctoral internship at Methodist Hospital in Dallas, TX. He went on to complete his residency at University of Texas Southwestern Medical Center in Dallas, in anesthesia and a fellowship in pain management.

Dr. Willis would begin his professional career as an anesthesiologist, before transitioning into a practice primarily focused on pain management, and has run his own private practice over the last 20 years.