Hydrogels have been used successfully in many tissue engineering applications.  However, because they are inherently soft materials, it is not always easy to get the large, interconnected pore network that enhances cell behavior and allows neovascularization of implants.  Many techniques have been developed to try and create pore networks after the gelling process completes, like using salt or sugar porogens.  But porogens must be removed to create the pore network, and the removal process has always been the Achilles heel...

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