Featuring articles on the timing of endoscopy for acute upper gastrointestinal bleeding, multidrug-resistant bacterial infections in U.S. hospitalized patients, the U.S. burden of C. difficile infection, CD19-directed CAR T cells in refractory mantle-cell lymphoma, and creating a framework for conducting randomized clinical trials during disease outbreaks; a review article on anorexia nervosa; a Clinical Problem-Solving describing missing the target; and Perspective articles on stigma and the toll of addiction, on escaping Pandora’s box, and on waste, worry, and the seven sins of medicine.