Featuring articles on concizumab in hemophilia A or B with inhibitors, the timing of primary surgery for cleft palate, improved mass screening for nasopharyngeal carcinoma, gene editing for sickle cell disease, and on artificial sweeteners; a review article on informative artifacts in AI-assisted health care; a case report of a woman with celiac disease and upper gastrointestinal bleeding; and Perspective articles on Project NextGen, on gerineuropalliative care for patients with dementia, and on sexual and gender minority refugees.