Featuring articles on daratumumab in myeloma therapy, the early treatment of patent ductus arteriosus with ibuprofen, measurable residual disease in chronic lymphocytic leukemia, hospital prices for physician-administered drugs, and on Asian Americans and racial justice in medicine; a review article on wearable technologies in cardiovascular medicine; a case report of an infant with inconsolable crying and weakness; and Perspective articles on minding the gap, on transforming population health, and on the heartbeat.