Jennifer Doudna, co-discoverer of CRISPR-Cas9 and winner of the 2022 Nobel Prize in Chemistry, discusses how genome editing with CRISPR technology is transforming biology. CRISPR-Cas9, an RNA-guided enzyme with remarkable abilities to recognize and cleave DNA, operates by mechanisms that both explain its biological function and provide insights into technology development. Doudna covers research into this amazing family of proteins: where they came from, how they work and how CAS-9-based technologies are revolutionizing research, biomedicine and agriculture. Series: "Frontiers of Knowledge" [Science] [Show ID: 35215]