Although a variety of factors have been identified that predict the quality of life in patients with MS, these predictors have not been examined simultaneously to determine their relative importance. Two experts in the field, Dr. Timothy Vollmer and Dr. Ralph Benedict, discuss recent research identifying the primary predictors of physical and mental health QOL in patients with MS, as well as the most significant factors in predicting employability/vocational status-findings that have important implications for the management of patients with MS.