This week we discuss heart dedifferentiation and regeneration with Avraham Shakked @abingtonSA a final year PhD student, at the Weizmann Institute of Science, @WeizmannScience. We speak about their ingenious mouse model which uses transient and temporarily controlled ERBB2 expression which allows dedifferentiation and redifferentiation of cardiomyocytes. Using this model they examined the difference in RNA, protein and heart function in the redifferentiated the cells with and without heart injury. We also speak about preprints, publishing and alternative careers for scientists.

Read the full preprint: https://www.biorxiv.org/content/10.1101/2022.02.22.481415v1.full

This episode was produced by Emma Wilson and edited by John D Howard .

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Produced by JEmJ Productions (find us on Twitter: Jonny @JACoates, Emma @ELWilson92, John @JohnDHoward8) and generously supported by ASAPbio (https://asapbio.org | @asapbio_).

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