Nurses play a vast role in preventing the development of healthcare-associated infections (HAIs) and the spread of infectious diseases, such as COVID-19. In this episode, Dr. Anna Maria Valdez, PhD, RN, CEN, CFRN, CNE, FAEN, FAADN, a senior contributing faculty member at Walden University; Gloria Barrera, MSN, RN, PEL-CSN, a certified school nurse at a public high school outside of Chicago; and Dr. Michelle Crespo-Fierro, PhD, MPH, RN, AACRN, a clinical assistant professor at New York University Meyers College of Nursing, discuss the importance and challenges of infection control in nursing. Additionally, as part of the Centers for Disease Control & Prevention’s Project Firstline, they discuss infection control strategies and resources nurses can use to minimize the spread of COVID-19 and other diseases.